Our expertises

Discovery of molecules active on a specific biological target, development and application of novel computational methodologies to discover new biologically relevant compounds.

Synthesis

Multicomponent reactions

Aryne chemistry

Isocyanide chemistry

Click chemistry

In silico

Chemoinformatics algorithms

Molecular simulations

Virtual screening

De novo drug design

Identification of molecules

SAR studies

Molecular probes

Compound library design

Drug repositioning

 

Research topics

Tubulin

Anti-Colchi site compounds

HDAC

Zn-chelating agents

NMPRTase

Anticancer compounds

PI3K

ATP mimetics

Click chemistry

Fast, simple reactions

MCR

Multicomponent Reactions

The Team

Every member is indipendent and free to follow his/her research interests, undertake collaborative projects and independently publish.

Giovanni Sorba

Full professor

His research interests have shifted through the years from the synthesis and development of H2 antagonists, H3 agonists and antagonists, and H+/K+ ATP-ase inhibitors to the discovery of novel heterocyclic derivatives in the field of oncology.

Gian Cesare Tron

Associate professor

His research interests concern the discovery of new multicomponent reactions and their applications in the field of medicinal chemistry and the discovery of new antitumoral agents (tubulin inhibitors, HDAC inhibitors, NAD+ syntesis inhibitors).

Tracey Pirali

Associate professor

Her main area of interest is the synthesis of bioactive compounds of medicinal relevance, especially in the realm of cancer treatment (tubulin, phosphatidylinositol 3-kinases, istone deacetylases, indoleamine 2,3-dioxygenase). Recently, she has been interested in the development of novel ligands for TRP channels.

Ubaldina Galli

Assistant professor

Her research interests have shifted through the years from the synthesis on NO-donors as antimalaric and antiulcer drugs to the synthesis of selective PI3 kinases inhibitors as antitumoral, antiinflammatory and anticoagulant drugs.

Alberto Massarotti

Assistant professor

His research interests include the development and application of novel computational methodologies to discover new lead compounds.
 

Valentina Mercalli

Post-doc

Tutor: Dr. A. Massarotti
 
 
 

Alessia Griglio

Ph.D. student

Tutor: Prof.ssa T. Pirali



Marta Serafini

Ph.D. student

Tutor: Prof.ssa T. Pirali






Doriana Levré

Fellow

Tutor: Dr. A. Massarotti






Chiara Arcisto

Fellow

Tutor: Dr. A. Massarotti






Cecilia Carvoli

Undergraduate student

Tutor: Dr. A. Massarotti

Davide Pompa

Undergraduate student

Tutor: Prof. T. Pirali

Luca Bertarello

Undergraduate student

Tutor: Prof. T. Pirali

Malika Laaguid

Undergraduate student

Tutor: Dr. U. Galli

Rejdia Hysenlika

Undergraduate student

Tutor: Prof. G. C. Tron

Cristiana Necardo

Undergraduate student

Tutor: Prof. G. C. Tron

Alberto Gozeni

Undergraduate student

Tutor: Prof. T. Pirali

Beatrice Galli

Undergraduate student

Tutor: Dr. U. Galli

Martina Saltarelli

Undergraduate student

Tutor: Prof. G. C. Tron

 

Publications

On-water pyrrolidine-mediated domino synthesis of 2-iminoisatins

Green Chem. 2018, ASAP, -

Pelliccia S., Abbate V., Meneghetti F., Frascione N., Hider R.C., Novellino E., Tron G.C., Giustiniano M.

Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island

Synthesis 2018, ASAP, -

Giustiniano M., Moni L., Sangaletti L., Pelliccia S., Basso A., Novellino E., Tron G.C.

Arynes and isocyanides: Two close-knit partners in multicomponent reactions

Drug Discovery Today: Technologies 2018, ASAP, -

Serafini M., Pirali T.

Contact Us

  • Address: L.go Donegani 2, 28100 Novara (Italy)
  • Phone: +39 0321 375 857
  • Fax: +39 0321 375 621
  • Email: info@symech.it