Our expertises

Discovery of molecules active on a specific biological target, development and application of novel computational methodologies to discover new biologically relevant compounds.

Synthesis

Multicomponent reactions

Aryne chemistry

Isocyanide chemistry

Click chemistry

In silico

Chemoinformatics algorithms

Molecular simulations

Virtual screening

De novo drug design

Identification of molecules

SAR studies

Molecular probes

Compound library design

Drug repositioning

 

Research topics

Tubulin

Anti-Colchi site compounds

HDAC

Zn-chelating agents

NMPRTase

Anticancer compounds

PI3K

ATP mimetics

Click chemistry

Fast, simple reactions

MCR

Multicomponent Reactions

The Team

Every member is indipendent and free to follow his/her research interests, undertake collaborative projects and independently publish.

Gian Cesare Tron

Professor

His research interests concern the discovery of new multicomponent reactions and their applications in the field of medicinal chemistry and the discovery of new antitumoral agents (tubulin inhibitors, HDAC inhibitors, NAD+ syntesis inhibitors).

Tracey Pirali

Associate professor

Her main area of interest is the synthesis of bioactive compounds of medicinal relevance, especially in the realm of cancer treatment (tubulin, phosphatidylinositol 3-kinases, istone deacetylases, indoleamine 2,3-dioxygenase). Recently, she has been interested in the development of novel ligands for TRP channels.

Alberto Massarotti

Associate professor

His research interests include the development and application of novel computational methodologies to discover new lead compounds.
 

Ubaldina Galli

Assistant professor

Her research interests have shifted through the years from the synthesis on NO-donors as antimalaric and antiulcer drugs to the synthesis of selective PI3 kinases inhibitors as antitumoral, antiinflammatory and anticoagulant drugs.

Marta Serafini

Ph.D. student

Tutor: Prof.ssa T. Pirali






Irene Preet Bhela

Fellow

Tutor: Prof.ssa T. Pirali






Beatrice Galli

Undergraduate student

Tutor: Dr. U. Galli

Nicoḷ Tonello

Undergraduate student

Tutor: Prof. A. Massarotti

Marzia Petreti

Undergraduate student

Tutor: Prof. G. C. Tron

Merita Kopani

Undergraduate student

Tutor: Prof. T. Pirali

Martina Esposito

Undergraduate student

Tutor: Prof. A. Massarotti

Mirko Rancan

Undergraduate student

Tutor: Prof. T. Pirali

Francesca Brunelli

Undergraduate student

Tutor: Prof. G. C. Tron

Lorenzo Cerutti

Undergraduate student

Tutor: Prof. A. Massarotti

Valerio Pazienza

Undergraduate student

Tutor: Prof. G. C. Tron

Natasha Barbato

Undergraduate student

Tutor: Prof. G. C. Tron

Chiara Grignani

Undergraduate student

Tutor: Prof. T. Pirali

Aurora Parisotto

Undergraduate student

Tutor: Prof. T. Pirali

Christian Rampinelli

Undergraduate student

Tutor: Prof. G. C. Tron

Pietro Citati

Undergraduate student

Tutor: Prof. A. Massarotti

Alessia Gaia Lembo

Undergraduate student

Tutor: Prof. A. Massarotti

Alice Ranza

Undergraduate student

Tutor: Prof.ssa T. Pirali

Miriam Alberti

Undergraduate student

Tutor: Prof.ssa T. Pirali

Oscar Mapelli

Undergraduate student

Tutor: Prof. A. Massarotti

Sarah-Jane Rezzi

Undergraduate student

Tutor: Prof.ssa T. Pirali

Claudia Ventura

Undergraduate student

Tutor: Prof. G.C. Tron

 

Publications

Psychotropic drugs show anticancer activity by distrupting mitochondrial and lysosomal function

Front. Oncol. 2020, , -

Varalda M., Antona A., Bettio V., Roy K., Vachanaram A.R., Yellenki V., Massarotti A., Baldanzi G., Capello D.

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy

Front. Pharmacol. 2020, , -

Galli U., Colombo G., Travelli C., Tron G.C., Genazzani A.A., Grolla A.A.

The Essential Medicinal Chemistry of Essential Medicines

J. Med. Chem. 2020, 63, 10170-10187

Serafini M., Cargnin Sarah, Massarotti A., Pirali T., Genazzani A.A.

Contact Us

  • Address: L.go Donegani 2, 28100 Novara (Italy)
  • Phone: +39 0321 375 857
  • Fax: +39 0321 375 621
  • Email: info@symech.it