Discovery of molecules active on a specific biological target, development and application of novel computational methodologies to discover new biologically relevant compounds.
De novo drug design
Identification of molecules
Compound library design
Every member is indipendent and free to follow his/her research interests, undertake collaborative projects and independently publish.
Gian Cesare Tron
His research interests concern the discovery of new multicomponent reactions and their applications in the field of medicinal chemistry and the discovery of new antitumoral agents (tubulin inhibitors, HDAC inhibitors, NAD+ syntesis inhibitors).
Her main area of interest is the synthesis of bioactive compounds of medicinal relevance, especially in the realm of cancer treatment (tubulin, phosphatidylinositol 3-kinases, istone deacetylases, indoleamine 2,3-dioxygenase). Recently, she has been interested in the development of novel ligands for TRP channels.
His research interests include the development and application of novel computational methodologies to discover new lead compounds.
Her research interests have shifted through the years from the synthesis on NO-donors as antimalaric and antiulcer drugs to the synthesis of selective PI3 kinases inhibitors as antitumoral, antiinflammatory and anticoagulant drugs.