Verza A., Miggiano R., ..., Del Grosso E., Galli U., Rizzi M., Rossi F.
Publications
Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues
Curr Res Struct Biol 2022, 4, 246-255
Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity
Molecules 2022, 27, 6218-Nichugovskiy A., ..., Tron G.C., Maslov M.
Brunelli F., Aprile S., Russo C., Giustiniano M., Tron G.C.
Visible-light photocatalytic metal-free multicomponent Ugi-like chemistry
Green Chem. 2022, 24, 3993-4003Russo C., Graziani G., Cannalire R., Tron G.C., Giustiniano M.
Photomicellar Catalyzed Synthesis of Amides from Isocyanides: Optimization, Scope, and NMR Studies of Photocatalyst/Surfactant Interactions
ACS Org. Inorg. Au 2022, 2, 66-74Cannalire R., Santoro F., Russo C., Graziani G., Tron G.C., Carotenuto A., Brancaccio D., Giustiniano M.
Russo C., Brunelli F., Tron G.C., Giustiniano M.
Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization
Mol. Div. 2022, , -Cannalire R., Russo C., Paolo Luciano, Bruno Cerra, Antimo Gioiello, Francesca Brunelli, Gian Cesare Tron & Mariateresa Giustiniano
The Dark Side of Isocyanides: Visible-Light Photocatalytic Activity in the Oxidative Functionalization of C(sp3)–H Bonds
J. Org. Chem. 2021, 86, 18117-18127Russo C., Amato J., Tron G.C., Giustiniano M.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation
Science 2021, 374, 1339-Gulluni F., Prever L., Li H., ..., Massarotti A., ..., Hirsch E.
Visible-Light Photocatalytic Ugi/Aza-Wittig Cascade towards 2-Aminomethyl-1,3,4-oxadiazole Derivatives
Synthesis 2021, 53, 4419-4427Russo C, Cannalire R., Luciano P., Brunelli F., Tron G.C., Giustiniano M.
Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications
Molecules 2021, 26, 6579-Nichugovskiy A., Tron G.C., Maslov M
Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds
Int. J. Mol. Sci. 2021, 22, 11959-Di Porzio A., Galli U., Amato J., ..., Tron G.C., Randazzo A.
Multicomponent reaction between (Z)-chloroximes, isocyanides and NH-heterocyclic rings
Tetrahedron Letters 2021, 86, -Brunelli F., Russo C., Giustiniano M, Tron G.C.
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors
ChemMedChem 2021, 16, 3439-3450Fallarini S., Bhela I.P., Aprile S., Torre E., Ranza A., Orecchini E., Panfili E., Pallotta M.T., Massarotti A., Serafini M., Pirali T.
Massarotti A., Brunelli F., Aprile S., Giustiniano M., Tron G.C.
Tron G.C., Minassi A., Sorba G., Fausone M., Appendino G.
Tritylamine as an Ammonia Surrogate in the Ugi Reaction Provides Access to Unprecedented 5-Sulfamido Oxazoles Using Burgess-type Reagents
Org Lett. 2021, 23, 3610-3614Bhela I.P., Serafini M., Del Grosso E., Tron G.C., Pirali T.
1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry
ACS Med Chem Lett 2021, 12, 640-646Aprile S., Riva B., Bhela I.P., Cordero-Sanchez C., Avino G., Genazzani A.A., Serafini M., Pirali T.
What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications
J. Med. Chem. 2021, 64, 4410-4429Serafini M., Cargnin S., Massarotti A., Tron G.C., Pirali T., Genazzani A.A.
Adamo A., Frusteri C., Pallotta M.T., Pirali T., Sartoris S., .Ugel S
The 115 Year Old Multicomponent Bargellini Reaction: Perspectives and New Applications
Molecules 2021, 26, 558-Serafini M., Murgia I., Giustiniano M., Pirali T., Tron G.C.
Therapeutic Peptides for the Treatment of Cystic Fibrosis: Challenges and Perspectives
Eu. J. Med. Chem. 2021, 213, 113191-Sala V., Cnudde S., Murabito A., Massarotti A., Hirsch E., Ghigo A.
Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds
Chem. Soc. Rev. 2021, ASAP, -Cannalire R., Pelliccia S., Sancineto L., Novellino E., Tron G.C., Giustiniano M
Click 1,2,3-triazoles in drug discovery and development: from the flask to the clinic?
Advances in Heterocyclic Chemistry 2021, ASAP, -Serafini M., Pirali T., Tron G.C.
The SNAP-tag technology revised: an effective chemo-enzymatic approach by using a universal azide-based substrate
J Enzyme Inhib Med Chem 2021, 36, 85-97Merlo R., Caprioglio D., Cillo M., Valenti A., Mattossovich R., Morrone C., Massarotti A., Rossi F., Miggiano R., Leonardi A., Minassi A., Perugino G.
Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals
J. Org. Chem. 2020, 85, 14077-14086Cannalire R., Amato J., Summa V., Novellino E., Tron G.C., Giustiniano M.
Psychotropic drugs show anticancer activity by distrupting mitochondrial and lysosomal function
Front. Oncol. 2020, , -Varalda M., Antona A., Bettio V., Roy K., Vachanaram A.R., Yellenki V., Massarotti A., Baldanzi G., Capello D.
Galli U., Colombo G., Travelli C., Tron G.C., Genazzani A.A., Grolla A.A.
Serafini M., Cargnin S., Massarotti A., Pirali T., Genazzani A.A.
Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity
J. Med. Chem. 2020, 63, 3047-3065Serafini M., Torre E., Aprile S., Del Grosso E., Gesù A., Griglio A., Colombo G., Travelli C., ..., Massarotti A., Pirali T., Fallarini S.
The metabolic fate of the isocyanide moiety. Are isocyanides pharmacophore groups neglected by medicinal chemists?
Chem. Res. Toxicol. 2020, 33, 955-966Galli U., Tron G.C., Purghè B., Grosa G., Aprile S.
A nicotinamide phosphoribosyltransferase–GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus
J. Biol. Chem 2020, 295, 3635-3651Grolla A., Miggiano R., ..., Galli U., Del Grosso E., ..., Genazzani A.A., Garavaglia S.
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
Data in brief 2020, 28, 105034-Aprile S., Galli U., Tron G.C., Del Grosso E., Travelli C., Grosa G.
Photocatalytic Isocyanide-based Multicomponent Domino Cascade Towards the Stereoselective Formation of Iminofurans
J. Org. Chem. 2020, 85, 1981-1990Pelliccia S., Alfano A.I., Luciano P., Novellino E., Massarotti A., Tron G.C., Ravelli D., Giustiniano M.
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives
J. Med. Chem. 2020, 63, 2035-2050Pelliccia S., Amato J., Capasso D., Di Gaetano S., Massarotti A., Piccolo M., Irace C., Tron G.C., Pagano B., Randazzo A., Novellino E., Giustiniano M.
Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors
J Enzyme Inhib Med Chem 2020, 35, 96-108Velnati S., Massarotti A., Antona A., Talmon M., Fresu L.G., Galetto A.S., Capello D., Bertoni A., Mercalli V., Graziani A., Tron G.C., Baldanzi G.
A luminal EF-hand mutation in STIM1 in mice causes the clinical hallmarks of tubular aggregate myopathy
Dis Model Mech 2020, 13, -Cordero-Sanchez C., Riva B., Reano S., Clemente N., Zaggia I., Ruffinatti F.A., Potenzieri A., Pirali T., Raffa S., Sangaletti S., Colombo M.P., Bertoni A., Garibaldi M., Filigheddu N., Genazzani A.A.
Aryl azides as forgotten electrophiles in the Van Leusen reaction: a multicomponent transformation affording 4-tosyl-1-arylimidazoles
J. Org. Chem. 2019, 84, 16299-16307Necardo C., Alfano A.I., Del Grosso E., Pelliccia S., Galli U., Novellino E., Meneghetti F., Giustiniano M., Tron G.C.
Cargnin S., Serafini M., Pirali T.
Aprile S., Serafini M., Pirali T.
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group
Eur. J. Med. Chem. 2019, 181, 111576-Travelli C., Aprile S., ..., Grosa G., Genazzani A., Tron G.C., Galli U.
α-Amino Acids as Synthons in the Ugi-5-Centers-4-Components Reaction: Chemistry and Applications
Symmetry 2019, 11, 798-Pelliccia S., Alfano I.A., Galli U., Novellino E., Giustiniano M., Tron G.C.
Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method
JPBA 2019, 173, 154-161Canavesi R., Miggiano R., Stella M., Galli U., Rossi F., Rizzi M., Del Grosso E.
Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines
Molecules 2019, 24, 1959-Galli U., Hysenlika R., Meneghetti F., Del Grosso E., Pelliccia S., Novellino E., Giustiniano M., Tron G.C.
Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors
Molecules 2019, 24, 1874-Serafini M., Torre E., Aprile S., Massarotti A., Fallarini S., Pirali T.
Drug Discovery for Soft Drugs on TRPV1 and TRPM8 Channels Using the Passerini Reaction
Methods Mol Biol. 2019, 1987, 207-221Pirali T., Galli U., Serafini M., Griglio A., Genazzani A.A., Tron G.C.
Nicotinamide Phosphoribosyltransferase (NAMPT) acts as a metabolic gate for mobilization of myeloid-derived suppressor cells
Cancer Res. 2019, 79, -Travelli C., Consonni F.M., Sangaletti S., Storto M., Morlacchi S., Grolla A.A., Galli U., Tron G.C., Portararo P., Rimassa L., Pressiani T., Mazzone M., Trovato R., Ugel S., Bronte V., Tripodo C., Colombo M.P., Genazzani A.A., Sica A.
Pirali T., Serafini M., Cargnin S., Genazzani A.A.
Identification of a novel DGKα Inhibitor for XLP-1 Therapy by Virtual Screening
Eu. J. Med. Chem. 2019, 164, 378-390Velnati S., Ruffo E., Massarotti A., Talmon M., Sandeep Varma K.S., Gesù A., Fresu L.G., Snow A.L., Bertoni A., Capello D., Tron G.C., Graziani A., Baldanzi G.
Levré D., Arcisto C., Mercalli V., Massarotti A.
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
Nat. Commun. 2018, 9, 5232-Campa C.C., Silva R.L., Margaria J.P., Pirali T., Mattos M.S., Kraemer L.R., Reis D.C., Grosa G., Copperi F., Dalmarco E.M., Lima-Júnior R.C.P., Aprile S., Sala V., Dal Bello F., Prado D.S., Alves-Filho J.C., Medana C., Cassali G.D., Tron G.C., Teixeira M.M., Ciraolo E., Russo R.C., Hirsch E.
Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling and In Vivo Proof-of-Concept Efficacy in Acute Pancreatitis
J. Med. Chem. 2018, 61, 9756-9783Riva B., Griglio A., Serafini M., Cordero Sanchez C., Aprile S., Di Paola R., Gugliandolo E., Alansary D., Biocotino I., Lim D., Grosa G., Galli U., Niemeyer B., Sorba G., Canonico P.L., Cuzzocrea S., Genazzani A.A., Pirali T.
Pelliccia S., Abbate V., Meneghetti F., Frascione N., Hider R.C., Novellino E., Tron G.C., Giustiniano M.
Interrupted Ugi and Passerini Reactions: An Underexplored Treasure Island
Synthesis 2018, 50, 3549-3570Giustiniano M., Moni L., Sangaletti L., Pelliccia S., Basso A., Novellino E., Tron G.C.
Arynes and isocyanides: Two close-knit partners in multicomponent reactions
Drug Discovery Today: Technologies 2018, 29, 35-41Serafini M., Pirali T.
Rational Discovery of (+)-(S)-Abscisic Acid as a Potential Antifungal Agent: a Repurposing Approach
Scientific Reports 2018, 8, 8565-Khedr A.M., Massarotti A., Mohamed M.E.
Targeting transient receptor potential vanilloid 1 (TRPV1) channel softly: the discovery of Passerini adducts as a topical treatment for inflammatory skin disorders
J. Med. Chem. 2018, 61, 4436-4455Serafini M., Griglio A., Aprile S., Seiti F., Travelli C., Pattarino F., Grosa G., Sorba G., Genazzani A.A., Gonzales-Rodriguez S., Butron L., Devesa I., Fernández-Carvajal A., Pirali T., Ferrer-Montiel A.
Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe
Biochem Biophys Res Commun 2018, 500, 698-703Rossi F., Morrone C., Massarotti A., Ferraris D.M., Valenti A., Perugino G., Miggiano R.
Non-hydrolytic chemoselective cleavage of Ugi tertiary amides: a mild access to N-substituted α-amino acid amides
Tetrahedron Lett. 2018, 59, 1196-1199Giustiniano M., Pelliccia S., Novellino E., Tron G.C.
A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: synthesis, biological investigation and docking studies
Bioorganic Med. Chem. Lett 2018, 28, 651-657Griglio A., Torre E., Serafini M., Bianchi A., Schmid R., Coda Zabetta G., Massarotti A., Sorba G., Pirali T., Fallarini S.
Opassi G., Gesù A., Massarotti A.
Preparation of capsaicinoid transient receptor potential vanilloid 1 (TRPV1) via Passerini multicomponent reaction and their pharmaceutical, veterinary and cosmetic compositions
PCT Int. Appl. 2018, WO 2018206, -Devesa G.I., Genazzani A.A., Pirali T., Fernandez-Carvajal A., Ferrer-Montiel A.V.
Pirali T., Genazzani A.A., Riva B.
The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides
Tetrahedron Lett. 2017, 58, 4786-4789Serafini M., Griglio A., Oberto E., Pirali T., Tron G.C.
Amphoteric 2-(Sulfonylamino)Benzaldehydes, Secondary Amines and Isocyanides in the Multicomponent Synthesis of Elusive N-Alkyl-2,3-diaminoindoles
Tetrahedron Lett. 2017, 58, 4264-4268Giustiniano M., Pelliccia S., Sangaletti L., Meneghetti F., Amato J., Novellino E., Tron G.C.
Serafini M., Griglio A., Viarengo S., Aprile S., Pirali T.
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
ChemMedChem 2017, 12, 1542-1554Pirali T., Ciraolo E., Aprile S., Massarotti A., Berndt A., Griglio A., Serafini M., Mercalli V., Landoni C., Cosimo Campa C., Margaria J.P., Silva R.L., Grosa G., Sorba G., Williams R., Hirsch E., Tron G.C.
Ferrer Montiel A.V., Fernandez Carvajal A., Belmonte M.C., Gallar M.J., De La Torre R., Genazzani A.A., Tron G.C., Mercalli V.
A Fast Route for the Synthesis of Tetrazolyl Oximes by a Novel Multicomponent Reaction between Z-Chlorooximes, Isocyanides and Trimethylsilyl Azide
Tetrahedron Lett. 2017, 58, 3549-3553Giustiniano M., Pelliccia S., Muñoz-Garcia A.B., Pavone M., Pagano B., Galli U., Novellino E., Tron G.C.
Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis
Scientific Reports 2017, 7, 1180-Donini S., Ferraris D.F., Miggiano R., Massarotti A., Rizzi M.
Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Anti-Proliferative and Anti-Inflammatory Activity
J. Med. Chem. 2017, 60, 1768-1792Travelli C., Aprile S., Rahimian R., Grolla A.A., Rogati F., Bertolotti M., Malagnino F., Di Paola R., Impellizzeri D., Fusco R., Mercalli V., Massarotti A., Stortini G., Terrazzino S., Del Grosso E., Fakhfouri G., Pia Troiani M., Alisi M.A., Grosa G., Sorba G., Canonico P.L., Orsomando G., Cuzzocrea S., Genazzani A.A., Galli U., Tron G.C.
N–N bond formation in Ugi processes: from nitric acid to libraries of nitramines
Chem. Commun. 2017, 53, 2118-2121Mercalli V., Nyadanu A., Cordier M., Tron G.C., Grimaud L.,El Kaim L.
To each his own: isonitriles for all flavors. Functionalized isocyaides as valuable tools in organic synthesis
Chem. Soc. Rev. 2017, 46, 1295-1357Giustiniano M., Basso A., Mercalli V., Massarotti A., Novellino E., Tron G.C., Zhu J.
Interdomain interactions rearrangements control the reaction steps of a thermostable dna alkyltransferase
Biochimica et Biophysica Acta 2017, 2, 86-96Morrone C., Miggiano R., Serpe M., Massarotti A., Valenti A., del Monaco G., Rossi M., Rossi F., Rizzi M., Perugino G., Ciaramella M.
A Successful Replacement of Phenols with Isocyanides in the Bargellini Reaction: Synthesis of 3-Carboxamido-Isobutyric acids
J. Org. Chem. 2016, 81, 11467-11471Giustiniano M., Pelliccia S., Galli U., Amato J., Travagin F., Novellino E., Tron G.C.
Bassetto M., Massarotti A., Coluccia A., Brancale A.
Bellomo E., Kshetrimayum Singh B., Massarotti A., Hogstrand C., Maret W.
Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions
Synthesis 2016, 48, 2721-2731Giustiniano M., Novellino E., Tron G.C.
Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α'-Disubstituted α-Isocyanoacetamides
Org. Lett. 2016, 18, 1992-1995Gesù A., Pozzoli C., Torre E., Aprile S., Pirali T.
An efficient synthesis of 1-arylindazole-3-carboxamides using nitrile imines, isocyanides and 2-hydroxymethylbenzoic acid, followed by a chemoselective Buchwald-Hartwig intramolecular cyclization.
RSC Adv. 2016, 6, 34913-34920Gustiniano M., Mercalli V., Novellino E., Tron G.C.
BDNF Val66Met and clinical response to antipsychotic drugs: a systematic review and meta-analysis
Eu. Psychiatry 2016, 33, 45-53Cargnin S., Massarotti A., Terrazzino S.
An in-silico approach aimed to clarify the role of Y181C and K103N HIV-1 reverse transcriptase mutations versus Indole Aryl Sulphones
J. Mol. Graph. Model. 2016, 63, 49-56Massarotti A., Coluccia A.
The Adverse Outcome Pathway (AOP) for chemical binding to tubulin in oocytes leading to aneuploid offspring
Environ. Mol. Mutagen. 2016, 57, 87-113Marchetti F., Massarotti A., Yauk C.L., Pacchierotti F., Russo A.
In silico-driven multicomponent synthesis of 4,5- and 1,5-disustituted imidazoles as indoleamine 2,3-dioxygenase inhibitors
Med. Chem. Commun. 2016, 7, 409-419Fallarini S., Massarotti A., Gesù A., Giovarruscio S., Coda Zabetta G., Bergo R., Giannelli B., Brunco A., Lombardi G., Sorba G., Pirali T.
The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors
Molecules 2015, 20, 17275-17287Galli U., Ciraolo E., Massarotti A., Margaria J.P., Sorba G., Hirsch E., Tron G.C.
Multicomponent Reaction of Z-chlorooximes, Isocyanides and Hydroxylamines as Hyper-nucleophilic Traps. A One-pot Route to Aminodioximes and Their Transformation into 5-amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement
J. Org. Chem. 2015, 80, 9652- 9661Mercalli V., Massarotti A., Varese M., Giustiniano M., Meneghetti F., Novellino E., Tron G.C.
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement
Med. Chem. Commun. 2015, 6, 1891-1897Theeramunkong S., Galli U., Grolla A.A., Caldarelli A., Travelli C., Massarotti A., Troiani M.P., Alisi M.A., Orsomando G., Genazzani A.A., Tron G.C
Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones
Org. Lett. 2015, 17, 3964-3967Giustiniano M., Mercalli V., Amato J., Novellino E., Tron G.C.
Marletta S.A., Massarotti A., Orsomando G., Magni G., Rizzi M., Garavaglia S.
Design, Synthesis and Biological Evaluation of Combretabenzodiazepines: a Novel Class of Antitubulin Agents
J. Med. Chem. 2015, 58, 1345-1357Galli U., Travelli C., Aprile S., Arrigoni E., Torretta S., Grosa G., Massarotti A., Sorba G., Canonico P.L., Genazzani A.A., Tron G.C.
Synthesis of Heteroarylogous 1H-Indole-3-Carboxamidines Through a Three-Component Interrupted Ugi Reaction
SYNTHESIS 2015, 47, 489-496La Spisa F., Meneghetti F., Pozzi B., Tron G.C.
Inhibitors of nicotinamide phosphoribosyltransferase, compositions, products and uses thereof
PCT Int. Appl. 2014, WO2014178001 (A1), -Genazzani A.A., Tron G.C., Galli U., Travelli C., Cuzzocrea S., Grosa G., Sorba G., Canonico P.L.
Sequential Multicomponent Synthesis of α-Ketoimides, from Acyl chlorides, Isocyanides and Silver Salts of Carboxylic Acids
Tetrahedron Lett. 2014, 55, 7060-7063La Spisa F., Tron G.C.
Solution phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides and electron deficient phenols
ACS Comb. Sci. 2014, 16, 602-605Mercalli V., Giustiniano M., Del Grosso E., Varese M., Cassese H., Massarotti A., Novellino E., Tron G.C.
Synthesis of Aminocarbonyl N-Acylhydrazones by a Three-Component Reaction of Isocyanides, Hydrazonoyl Chlorides, and Carboxylic Acids
Org. Lett. 2014, 16, 5332-5335Giustiniano M., Meneghetti F., Mercalli V., Varese M., Giustiniano F., Novellino E., Tron G.C.
Are 1,4- and 1,5-disubstituted-1,2,3-triazoles good pharmacophoric groups?
ChemMedChem 2014, 9, 2497-2508Massarotti A., Aprile S., Mercalli V., Del Grosso E., Grosa G., Sorba G., Tron G.C.
Reaction Between (Z)-Arylchlorooximes and alpha-Isocyanoacetamides: a Procedure For The Synthesis of Aryl-alpha-Ketoamide amides
J. Org. Chem. 2014, 79, 6006-6014Giustiniano M., Mercalli V., Cassese H., Di Maro S., Galli U., Novellino E., Tron G.C.
Bellomo E., Massarotti A., Hogstrand C., Maret W.
ZINClick: a database of 16 million novel, patentable and readily synthesizable 1,4-disubstituted triazoles
J. Chem. Inf. Model 2014, 54, 396-406Massarotti A., Brunco A., Sorba G., Tron G.C.
Elseginy S.A., Massarotti A., Nawwar G.A., Amin K.M., Brancale A.
Mercalli V., Meneghetti F., Tron G.C.
Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitors
J. Med. Chem. 2013, 56, 6279-6296Galli U., Travelli C., Massarotti A., Fakhfouri G., Rahimian R., Tron G.C., Genazzani A.A.
Off the beaten track: the use of secondary amines in the Ugi reaction
Eur. J. Org. Chem. 2013, 2013, 1849-1859Tron G.C.
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus
Antvir. Res. 2013, 98, 12-18Bassetto M., De Burghgraeve T., Delang L., Massarotti A., Coluccia A., Gatti V., Colombano G., Sorba G., Silvestri R., Tron G.C., Neyts J., Leyssen P., Brancale A.
A Concise Synthesis of Pyrazole Analogues of Combretastatin A1 as Potent Antitubulin Agents
ChemMedChem 2013, 8, 633-643Zaninetti R., Cortese S.V., Aprile S., Massarotti A., Canonico P.L., Sorba G., Grosa G., Genazzani A.A., Pirali T.
Utsintong M., Massarotti A., Caldarelli A., Theeramunkong S.
Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions
Pigment Cell Melanoma Res 2013, 26, 144-146Maldi E., Travelli C., Caldarelli1 A., Agazzone N., Cintura S., Galli U., Scatolini M., Ostano P., Miglino B., Chiorino G., Boldorini R., Genazzani A.A.
Isocyanide Chemistry. Applications in Synthesis and Material Science. Edited by Valentine G. Nenajdenko
Angew. Chem. Int. Ed. 2012, 51, 12659-12659Tron G.C.
An efficient synthesis of symmetric and unsymmetric bis-(β-aminoamides) via Ugi multicomponent reaction
Org. Lett. 2012, 14, 6044-6047La Spisa F., Feo A., Mossetti R., Tron G.C.
Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2
Eu. J. Med. Chem. 2012, 55, 58-66Galli U., Mesenzani O., Coppo C., Sorba G., Canonico P.L., Tron G.C., Genazzani A.A.
Quinolin-4 (1h)-one derivatives as inhibitors of phosphatidylinositol 3-kinases
PCT Int. Appl. 2012, WO 2012073, -Sorba G., Tron G.C., Galli U., Massarotti A., Hirsch E., Ciraolo E., Pirali T.
Braccini L., Ciraolo E., Martini M., Pirali T., Germena G., Rolfo K., Hirsch E.
Haptic-Driven applications to Molecular Modelling: State of the Art and Perspectives
Future Med. Chem. 2012, 4, 1219-1228Ricci A., Anthopoulos A., Massarotti A., Grimstead I., Brancale A.
The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
J. Neuroinflammation 2012, 9, 66-77Esposito E., Impellizzeri D., Mazzon E., Fakhfouri G., Rahimian R., Travelli C., Tron G.C., Genazzani A.A., Cuzzocrea S.
De novo computer-aided design of novel antiviral agents
Drug Discovery Today: Technologies 2012, 9, e213-e218Massarotti A., Coluccia A., Sorba G., Silvestri R., Brancale A.
Pirali T., Zhang F., Miller A.H., Head J.L., McAusland D., Greaney M.F.
Massarotti A., Coluccia A., Silvestri R., Sorba G., Brancale A.
Exploiting the Acylating Nature of the Imide-Ugi Intermediate: A Straightforward Synthesis of Tetrahydro-1,4-Benzodiazepin-2-Ones
J. Org. Chem. 2011, 76, 10258-10262Mossetti R., Saggiorato D., Tron G.C.
Identification of novel antitubulin agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin Colchi-site
Chem. Biol. Drug Des. 2011, 78, 913-922Massarotti A., Theeramunkong S., Mesenzani O., Caldarelli A., Genazzani A.A., Tron G.C.
Tron G.C., Minassi A., Appendino G.
Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues
J. Med. Chem. 2011, 54, 4977-4986Theeramunkong S., Caldarelli A., Massarotti A., Aprile S., Caprioglio D., Zaninetti R., Teruggi A., Pirali T., Grosa G., Tron G.C., Genazzani A.A.
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells
J. Pharm. Exp. Therap. 2011, 338, 829-840Travelli C., Drago V., Maldi E., Kaludercic N., Galli U., Boldorini R., Di Lisa F., Tron G.C., Canonico P.L., Genazzani A.A.
Stereospecific synthesis of syn-α-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids
Org. Lett. 2011, 13, 3734-3737Pirali T., Mossetti M., Galli S., Tron G.C.
Imides: Forgotten Players in the Ugi reaction. One pot multicomponent synthesis of quinazolinones
Chem. Comm. 2011, 47, 6966-6968Mossetti R., Pirali T., Saggiorato D., Tron G.C.
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors
Org. Biomol. Chem. 2011, 9, 4144-4149Guasconi M., Lu X., Massarotti A., Caldarelli A., Ciraolo E., Tron G.C., Hirsch E., Sorba G., Pirali T.
A novel a-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates
Org. Biomol. Chem. 2011, 9, 1627-1631Mossetti R., Caprioglio D., Colombano G., Tron G.C., Pirali T.
Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: synthesis and biological evaluation
Bioorg. Med. Chem. Lett. 2011, 21, 764-768Mesenzani O., Massarotti A., Giustiniano M., Pirali T., Bevilacqua V., Caldarelli A., Canonico P.L., Sorba G., Novellino E., Genazzani A.A., Tron G.C.
A Practical Synthesis of 5-Aroyl-1-aryltetrazoles Using an Ugi-Like 4-Component Reaction Followed by a Biomimetic Transamination
Synthesis 2010, 23, 4107-4118Giustiniano M., Pirali T., Massarotti A., Biletta B., Novellino E., Campiglia P., Sorba G., Tron G.C.
Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides
Org. Lett. 2010, 12, 820-823Mossetti R., Pirali T., Tron G.C., Zhu J.
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility
Mol. Biol. Cell. 2010, 21, 704-711Ciraolo E., Morello F., Hobbs R.M., Wolf F., Marone R., Iezzi M., Lu X., Mengozzi G., Altruda F., Sorba G., Guan K., Pandolfi P.P., Wymann M.P., Hirsch E.
Stereoselective synthesis of trans-beta-lactams by palladium-catalysed carbonylation of vinyl aziridines
Chem. Commun. 2010, 46, 267-269Fontana F., Tron G.C., Barbero N., Ferrini S., Thomas S.P., Aggarwal V.K.
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry
J. Med. Chem. 2010, 53, 616-623Colombano G., Travelli T., Galli U., Caldarelli A., Chini M.G., Canonico P.L., Sorba G., Bifulco G., Tron G.C., Genazzani A.A.
Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition
Mol. Divers. 2010, 14, 109-121Pirali T., Faccio V., Mossetti R., Grolla A.A., Di Micco S., Bifulco G., Genazzani A.A., Tron G.C.
Synthesis of Passerini-Ugi Hybrids by a Four-Component Reaction Using the Glycolaldehyde Dimer
J. Org. Chem. 2009, 74, 4890-4892Mossetti R., Pirali T., Tron G.C.
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases
J. Med. Chem. 2009, 52, 2776-2785Grolla A.A., Podestà V., Chini M.G., Di Micco S., Vallario A., Genazzani A.A., Canonico P.L., Bifulco G., Tron G.C., Sorba G., Pirali T.
Pirali T., Callipari G., Ercolano E., Genazzani A.A., Giovenzana G.B., Tron G.C.
Billington R.A., Travelli C., Ercolano E., Galli U., Roman C., Grolla A.A., Canonico P.L., Condorelli F., Genazzani A.A.
Solution-phase parallel synthesis and biological evaluation of combretatriazoles
J. Comb. Chem. 2008, 10, 732-740Cafici L., Pirali T., Condorelli F., Del Grosso E., Massarotti A., Sorba G., Canonico P.L., Tron G.C., Genazzani A.A.
Triazole-modified histone deacetylase inhibitors as a rapid route to drug discovery
J. Comb. Chem. 2008, 10, 624-627Pirali T., Pagliai F., Mercurio C., Boggio R., Canonico P.L., Sorba G., Tron G.C., Genazzani A.A.
Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage
ChemMedChem 2008, 3, 771-779Galli U., Ercolano E., Carraro L., Blasi Roman C.R., Sorba G., Canonico P.L., Genazzani A.A., Tron G.C., Billington R.A.
Click chemistry reactions in medicinal chemistry: applications of the 1,3-dipolar cycloaddition between azides and alkynes
Med. Res. Rev. 2008, 28, 278-308Tron G.C., Pirali T., Billington R., Canonico P.L., Sorba G., Genazzani A.
In vitro metabolism study of combretastatin A-4 in rat and human liver microsome
Drug Metab. Dispo. 2007, 35, 2252-2261Aprile S., Del Grosso E., Tron G.C., Grosa G.
Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide
Org. Lett. 2007, 9, 5275-5278Pirali. T., Tron G.C., Masson G., Zhu J.
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry
Bioorg. Med. Chem. 2007, 15, 6748-6757Imperio D., Pirali T., Galli U., Pagliai F., Cafici L., Canonico P.L., Sorba G., Genazzani A.A., Tron G.C.
Pirali T., Gatti S., Di Brisco R., Tacchi S., Zaninetti R., Brunelli E:, Massarotti A., Sorba G., Canonico P.L., Moro L., Genazzani A.A., Tron G.C., Billington R.A.
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase
Bioorg. Med. Chem. Lett. 2007, 17, 220-224Galli U., Oliaro-Bosso S., Taramino S., Venegoni S., Pastore E., Tron G.C., Balliano G., Viola F., Sorba G.
One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition
Org. Lett. 2006, 8, 4145-4148Pirali T., Tron G.C., Zhu J.
Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents
J. Med. Chem. 2006, 49, 5372-5376Pirali T., Busacca S., Beltrami L., Imovilli D., Pagliai F., Miglio G., Massarotti A., Verotta L., Tron G.C., Sorba G., Genazzani A.A.
Medicinal chemistry of combretastatin A-4: present and future directions
J. Med. Chem. 2006, 49, 3033-3044Tron G.C., Pirali T., Sorba G., Pagliai F., Busacca S., Genazzani A.A.
Split the primary amine in two: secondary diamines may play the role of the primary amine in the Ugi 4CR
Angew. Chem. Int. Ed. 2006, 45, 1099-1102Giovenzana G.B., Tron G.C., Di Paola S., Menegotto I.G., Pirali T.
Rapid synthesis of triazole-modified resveratrol analogues via click chemistry
J. Med. Chem. 2006, 49, 467-470Pagliai F., Pirali T., Del Grosso E., Di Brisco R., Tron G.C., Sorba G., Genazzani A.A.
Synthesis and biological activity of mustard derivatives of combretastatins
Bioorg. Med. Chem. Lett. 2005, 15, 3551-3554Coggiola B., Pagliai F., Allegrone G., Genazzani A.A., Tron G.C.
Tron G.C., Pagliai F., Del Grosso E., Genazzani A.A., Sorba G.
A three-component synthesis of (1,3-oxazol-2-yl)-1,2-dihydro(iso)quinoline and its further structural diversifications
Synlett 2005, 3, 532-534Tron G.C., Zhu J.
Billington R.A., Tron G.C., Reichenbach S., Sorba G., Genazzani A.A.